Haemoglobinopathies and pregnancy at the Bogodogo university hospital, ouagadougou, Burkina Faso.

Abstract

Introduction: Haemoglobinopathies are responsible for high morbidity and mortality, particularly when associated with pregnancy. We undertook this study of the association between haemoglobinopathies and pregnancy to help improve management. Materials and methods: This was a descriptive cross-sectional study with retrospective data collection at the Department of Obstetrics, Gynaecology and Reproductive Medicine, Bogodogo University Hospital, covering the period from 1 January 2020 to 31 December 2022. All pregnant women with SS, SC or CC genotype haemoglobinopathy admitted during the study period were included.
Results: During the study period, 130 cases  were recorded out of a total of 27671 admissions, a frequency of 0.5%. The mean age of the patients was 25 years. The proportion of heterozygous sickle cell SC patients was 60.8%. The main maternal complications at admission were vaso-occlusive crises (27.7%), acute chest syndrome (16.2%) and severe anaemia (10.8%). Vaginal delivery was used in 60.6% of cases, compared with 39.5% by caesarean section. Postpartum complications occurred in 25.8% of cases. The
case fatality rate was 7.7% and the stillbirth rate was 10.1%. Conclusion: Pregnancy in patients with sickle cell disease is a high-risk pregnancy for both mother and child. Good monitoring of these pregnancies seems essential to improve the maternal-fetal prognosis.